{"id":55,"date":"2021-03-19T10:44:02","date_gmt":"2021-03-19T14:44:02","guid":{"rendered":"https:\/\/prastera.com\/?page_id=55"},"modified":"2021-04-21T09:48:11","modified_gmt":"2021-04-21T13:48:11","slug":"all-cause-mortality","status":"publish","type":"page","link":"https:\/\/prastera.com\/?page_id=55","title":{"rendered":"All-Cause Mortality"},"content":{"rendered":"\n<p class=\"has-drop-cap has-pale-cyan-blue-background-color has-background\">The risk of death from any cause was five times higher in the placebo group than the treatment group (pooled data for the three United States clinical trials).&nbsp; The pooled placebo groups had an all-cause mortality rate of 7.8%, and the pooled treatment groups (treatment and cross-over) had an all-cause mortality rate of 1.6% (6 deaths in 77 placebo patients; 8 deaths in 495 treatment patients; <em>p<\/em> &lt; .00000001).&nbsp; Specific causes of death are provided in the Table below.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" width=\"675\" height=\"602\" src=\"https:\/\/prastera.com\/wp-content\/uploads\/2021\/03\/Risk-of-Death.jpg\" alt=\"\" class=\"wp-image-27\" srcset=\"https:\/\/prastera.com\/wp-content\/uploads\/2021\/03\/Risk-of-Death.jpg 675w, https:\/\/prastera.com\/wp-content\/uploads\/2021\/03\/Risk-of-Death-300x268.jpg 300w\" sizes=\"(max-width: 675px) 100vw, 675px\" \/><\/figure><\/div>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table><tbody><tr><td>Deaths during or following termination of study drug treatment<br>(Pooled Data &#8211; U.S. Studies)<\/td><\/tr><tr><td>Patient<br>ID #<\/td><td>Cause Of Death<\/td><td>Group<\/td><td>D<\/td><td>Interval<\/td><\/tr><tr><td>27206<\/td><td>Respiratory failure; massive bleeding<\/td><td>Placebo<\/td><td>125<\/td><td>2 months post study<\/td><\/tr><tr><td>12113<\/td><td>Respiratory failure; thrombotic microangiopathy<\/td><td>Drug*<\/td><td>95<\/td><td>14 weeks post study<\/td><\/tr><tr><td>13103<\/td><td>Pancreatitis<\/td><td>Drug<\/td><td>160<\/td><td>9 months post study<\/td><\/tr><tr><td>20511<\/td><td>Pulmonary hypertension\/restrictive lung disease<\/td><td>Placebo<\/td><td>206<\/td><td>on study<\/td><\/tr><tr><td>48817<\/td><td>Sudden Death<\/td><td>Placebo<\/td><td>80<\/td><td>on study<\/td><\/tr><tr><td>35712<\/td><td>Suicide<\/td><td>Placebo<\/td><td>5<\/td><td>on study<\/td><\/tr><tr><td>37495<\/td><td>Suicide<\/td><td>Placebo<\/td><td>177<\/td><td>on study<\/td><\/tr><tr><td>36571<\/td><td>Non-Hodgkin","protected":false},"excerpt":{"rendered":"<p>The risk of death from any cause was five times higher in the placebo group than the treatment group (pooled data for the three United States clinical trials).&nbsp; The pooled placebo groups had an all-cause mortality rate of 7.8%, and the pooled treatment groups (treatment and cross-over) had an all-cause mortality rate of 1.6% (6 &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/prastera.com\/?page_id=55\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;All-Cause Mortality&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":285,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/prastera.com\/index.php?rest_route=\/wp\/v2\/pages\/55"}],"collection":[{"href":"https:\/\/prastera.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/prastera.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/prastera.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/prastera.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=55"}],"version-history":[{"count":5,"href":"https:\/\/prastera.com\/index.php?rest_route=\/wp\/v2\/pages\/55\/revisions"}],"predecessor-version":[{"id":286,"href":"https:\/\/prastera.com\/index.php?rest_route=\/wp\/v2\/pages\/55\/revisions\/286"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prastera.com\/index.php?rest_route=\/wp\/v2\/media\/285"}],"wp:attachment":[{"href":"https:\/\/prastera.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=55"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}